The Dynamics of Tumor Microenvironment and Therapeutic Targets

The tumor microenvironment (TME) plays a significant role in influencing tumor aggressiveness and therapeutic outcomes, presenting both challenges and opportunities in oncology. The Dynamics of Tumor Microenvironment and Therapeutic Targets provides a detailed overview of the complex nature of the TME, highlighting its dynamic cellular and molecular components. Each chapter systematically examines a specific element of the TME, outlining its role in tumor initiation, progression, dormancy, and suppression. The book discusses the use of molecular inhibitors that disrupt tumor-promoting interactions within the TME. Additionally, it covers immune therapies designed to reprogram immune cells in the TME to enhance the effectiveness and durability of cancer treatments. This volume also addresses recent advancements in therapeutic strategies targeting the TME, including the incorporation of contemporary computational methods. Notably, the application of artificial intelligence (AI) and machine learning (ML) to TME analysis is explored, showcasing their utility in biomarker discovery and the development of precision oncology tools. Key Features Comprehensive coverage of the cellular and noncellular components of the TME, with an emphasis on their phenotypic and functional heterogeneity. Detailed discussion of both targetable and non-targetable elements of the TME and their relevance in therapeutic development. A dedicated chapter on AI-/ML-based methodologies for TME profiling, reflecting the emerging role of computational biology in oncology research. Critical descriptions of clinical trials targeting various aspects of the TME, alongside a synthesis of relevant translational and preclinical studies. This volume serves as a valuable resource for graduate students, early career researchers, and established investigators in cancer biology, tumor immunology, and translational oncology. It provides foundational knowledge as well as insights into emerging therapeutic paradigms centered on the TME.