Directed C-H Bond Functionalization: Concepts and Applications

Streamlined, cost-effective, and environmentally benign concepts for the synthesis of chemical building blocks and pharmaceuticals Directed C—H Bond Functionalization summarizes recent advances in the field of selective and efficient C—H bond functionalization using directing groups. Written by a team of experts in the field, Directed C—H Bond Functionalization includes information on: History of the C—H bond activation and its discovery In-built functional group-directed C—H functionalization, proximal C—H bond functionalization, and template-assisted distal C—H bond functionalization Transient-directing group-assisted C—H bond functionalization and bifunctional non-covalent template-assisted C—H functionalization Redox catalytic methods and metal-free directed C—H functionalization reactions Industrial and synthetic application of directed C—H bond functionalization in organic synthesis, medicinal, and process chemistry With its all-encompassing approach, Directed C—H Bond Functionalization is a timely, essential reference for synthetic chemists in academia and industry working in the fields of organic synthesis, catalysis, sustainable chemistry, and drug design.