Immunotherapy in Autoimmune Disorders: Mechanisms and Applications

This book offers a comprehensive review of the molecular and cellular mechanisms underlying autoimmune disorders, as well as the role of immunotherapy in managing these diseases. The initial chapter introduces the concept of tolerance, the immune system's capacity to distinguish between self and non-self. Further, it explores various factors that can disrupt this balance, leading to a breakdown of tolerance and the onset of autoimmune diseases. The book evaluates current strategies for managing autoimmune diseases, emphasizes their limitations, and introduces immunotherapeutic approaches. Furthermore, it delves into the latest advancements in immunosuppression, vaccine development, and the role of specific immune cells in autoimmune conditions. It discusses the generation of regulatory T cells (Tregs) and their therapeutic potential, as well as examines vaccines and myeloid-derived suppressor cells for preventing and treating autoimmune diseases. Additionally, the book addresses a revolutionary approach, chimeric antigen receptor T-cell (CART) therapy, for treating autoimmune disorders. Toward the end, the book examines the role of the gut microbiome on immune function and autoimmunity. It considers innovative drug delivery strategies as the future of personalized medicine in managing autoimmune diseases. This book is a valuable resource for researchers and students in immunology, microbiology, and pharmaceutical sciences. Key Features Explores promising new frontiers in next-generation immunotherapy for autoimmune diseases Reviews the role of factors leading to the loss of immune tolerance and existing autoimmune disease management Examines innovative drug delivery strategies and the therapeutic potential of nutraceuticals against autoimmune diseases Reviews the role and therapeutic potential of gut microbiome in autoimmune disorders Presents the therapeutic potential of Tregs, chimeric antigen receptor T-cell therapy, and myeloid-derived suppressor cells in treating autoimmune diseases