Signal Transduction in Mast Cells and Basophils

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.