Tuberculous spondylitis

Tuberculous spondylitis—also known as Pott's disease—is a severe and often debilitating form of spinal tuberculosis that continues to challenge clinicians, researchers, and public health officials, particularly in regions with high TB prevalence. This comprehensive volume serves as a definitive resource for medical professionals, researchers, and postgraduate students seeking an in-depth understanding of this complex condition. Drawing upon the latest clinical evidence, epidemiological trends, and treatment strategies, Tuberculous Spondylitis: A Comprehensive Clinical and Research Guide explores the disease from every angle—covering its pathogenesis, clinical presentation, diagnostic strategies, therapeutic approaches, and long-term outcomes. The book begins with a detailed account of the global burden of spinal tuberculosis and historical insights into its identification and evolution as a clinical entity. It then transitions into a scientific exploration of the etiopathogenesis of Mycobacterium tuberculosis in the vertebral column, highlighting mechanisms of spread, immune responses, and tissue destruction. Clinicians will find practical chapters on symptomatology, radiological findings, and differential diagnoses—equipping them with tools to distinguish tuberculous spondylitis from other causes of vertebral osteomyelitis or neoplastic lesions. State-of-the-art imaging techniques, including MRI and CT, are discussed in detail, supported by illustrative case studies and imaging examples that enhance diagnostic confidence. One of the core strengths of this book is its exhaustive treatment section. Both conservative medical management and surgical interventions are analyzed with clarity and precision. The authors delve into anti-tubercular therapy regimens, duration of treatment, challenges of drug resistance, and criteria for surgical decision-making. Surgical options—including debridement, stabilization, and spinal fusion—are explored with attention to anatomical, biomechanical, and rehabilitation considerations. Special focus is given to pediatric and geriatric cases, immunocompromised patients, and individuals with multidrug-resistant TB, addressing the nuances that affect prognosis and therapeutic planning. Additionally, the book covers rehabilitation strategies, long-term follow-up, and socioeconomic implications of spinal deformity and neurological compromise in affected patients. With contributions from experienced orthopedic surgeons, infectious disease specialists, neurologists, and radiologists, this volume integrates multidisciplinary perspectives to provide a holistic approach to care. A dedicated section on current research trends, emerging diagnostic biomarkers, molecular techniques, and advances in vaccine development positions this book at the forefront of academic inquiry into spinal tuberculosis. Richly detailed yet clinically focused, Tuberculous Spondylitis is an essential addition to medical libraries, serving as both a reference text and a practical guide. Whether you are a practicing physician in infectious disease or orthopedics, a medical student, or a public health policymaker, this book equips you with the knowledge and context needed to effectively diagnose, manage, and prevent one of the most severe extrapulmonary manifestations of tuberculosis. Key Features: Comprehensive clinical guide to diagnosis and management Detailed imaging and surgical techniques Multidrug resistance and special populations addressed Current research and future directions explored Global perspective with local applicability This book is more than a clinical manual—it is a commitment to the eradication of spinal TB and the restoration of mobility and dignity to those affected.